OUHSC Department of Physiology

1. Daniel J. Payette, Jun Xie, Najeeb Shirwany, and Qing Guo. Exacerbation of apoptosis of cortical neurons following traumatic brain injury in Par-4 transgenic mice. International Journal of Clinical and Experimental Pathology 2008; 1: 44-56
2. Najeeb A Shirwany, Daniel Payette, and Qing Guo. The amyloid beta ion channel hypothesis of Alzheimer’s disease: A review. Neuropsychiatric Disease and Treatment. 2007: 3(5) 597-612.
3. Daniel J. Payette, Jun Xie, and Qing Guo. Reduction in CHT1-mediated choline uptake in primary neurons from presenilin-1 M146V mutant knock-in mice. Brain Res. 2007; 1135: 12-21
4. Jun Xie, and Qing Guo. Par-4 is Novel Mediator of Renal Tubule Cell Death in Models of Ischemia-Reperfusion Injury. Am. J. Physiol. Renal Physiol., 2007; 292(1): F107-F115.
5. Grant A. Morgan, Qing Guo, Sic L. Chan, Devin S. Gary, Barbara A. Osborne, and Mark P. Mattson. Defects of Immune Regulation in the Presenilin-1 Mutant Knock-in Mouse. Neuromolecular Med.. 2007; 9: 35-46.
6. Jun Xie, and Qing Guo. Apoptosis Antagonizing Transcription Factor Protects Renal Tubule Cells against Oxidative Damage and Apoptosis Induced by Ischemia-Reperfusion. J. Am. Soc. Nephrol. 2006; 17(12): 3336-3346.
7. Guo Qing. When good Cdk5 turns bad. Sci Aging Knowledge Environ 2006, pe5.
8. Jun Xie, and Qing Guo. Par-4 Is involved in regulation of beta -secretase cleavage of the Alzheimer’s amyloid precursor protein. J Biol Chem., 2005; 280(14): 13824-13832.
9. Jun Xie, Keytam S. Awad, and Qing Guo. RNAi knockdown of Par-4 inhibits neurosynaptic degeneration in ALS-linked mice. J Neurochem. 2005; 92, 59-71.
10. Qing Guo. BRI-Aeta40 Transgenic Mice: Mice that produce human Aß1-40 in the absence of human amyloid precursor protein production do not develop amyloid-related pathologies. Sci. Aging Knowl. Environ. 2005 (32), tg5. [DOI: 10.1126/sageke.2005.32.tg5]
11. Qing Guo. BRI-Aeta42 Transgenic Mice: Mice that produce human Aß1-42 in the absence of human amyloid precursor protein production develop amyloid-related pathologies. Sci. Aging Knowl. Environ. 2005 (32), tg6. [DOI: 10.1126/sageke.2005.32.tg6]
12. Jun Xie, and Qing Guo. AATF protects neural cells against oxidative damage induced by amyloid beta-peptide. Neurobiol Dis 2004; 16, 150-157.
13. Jun Xie, and Qing Guo. Par-4 inhibits choline uptake by interacting with CHT1 and reducing its incorporation on the plasma membrane. J Biol Chem 2004; 279, 28266-28275.
14. Qing Guo, and Xie, J. AATF inhibits aberrant production of amyloid beta peptide 1-42 by interacting directly with Par-4. J Biol Chem 2004; 279, 4596-4603
15. Guo, Q. Cyclin-dependent kinase 5--a neuronal killer? Sci Aging Knowledge Environ 2003, pe36.
16. Qing Guo, Jun Xie, Xiaowei Chang, and Huimin Du. Prostate Apoptosis Response-4 Enhances Secretion of Amyloid beta Peptide 1-42 in Human Neuroblastoma IMR-32 Cells by a Caspase-dependent Pathway. J. Biol. Chem. 2001; 276: 16040-16044
17. Qing Guo, Jun Xie, Xiaowei Chang, Xiaojin Zhang and Huimin Du: Par-4 is a synaptic protein that regulates neurite outgrowth by altering calcium homeostasis and transcription factor AP-1 activation. Brain Res. 2001; 903(1-2): 13-25.
18. Jun Xie, Xiaowei Chang, Xiaojin Zhang and Qing Guo. Aberrant Induction of Par-4 is Essential for Degeneration of Hippocampal Neurons in Presenilin-1 M146V Mutant Knock-in Mice. Brain Res. 2001; 915(1): 1-10.
19. Qing Guo, Jun Xie, and Huimin Du. Par-4 Induces cholinergic hypoactivity by suppressing ChAT protein synthesis and inhibiting NGF-inducibility of ChAT activity. Brain Res. 2000; 874(2): 221-232
20. Jun Xie, Qing Guo, Haiyan Zhu, Marie W. Wooten and Mark P. Mattson. Protein Kinase C iota Protects Neurons Against Apoptosis Induced By Amyloid -Peptide. Brain Res Mol Brain Res. 2000; 82, 107-13.
21. Qing Guo, Weiming Fu, Bryce Sopher, Miles W. Miller, Carol B. Ware, George M. Martin, and Mark P. Mattson. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice. Nature Medicine 1999; 5: 101-107.
22. Qing Guo, Lois Sebastian, Bryce Sopher, Miles W. Miller, Gordon W. Glazner, Carol B. Ware, George M. Martin, and Mark P. Mattson. Neurotrophic factors (ADNF and bFGF) interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation. Proc. Natl. Acad. Sci. USA. 1999; 96(7): 4125-4130
23. Qing Guo, Lois Sebastian, Bryce Sopher, Miles W. Miller, Carol B. Ware, George M. Martin, and Mark P. Mattson. Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid -peptide toxicity: central roles of superoxide production and caspase activation. J. Neurochem. 1999; 72: 1019-1029.
24. Qing Guo, W. Fu, B. L. Sopher, F. W. Holtsberg, M. Miller, S. M. Steiner, G. M. Martin, and M. P. Mattson. Superoxide production mediates the apoptosis-enhancing action of presenilin-1 mutations: effect of overexpression of MnSOD. J. Neurosci. Res. 1999; 56(5): 457-470
25. Mark P. Mattson, Qing Guo. The Presenilins Neuroscientist 1999; 5(2): 112-124
26. Zhu, H., Qing Guo, and Mark p. Mattson. Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation. Brain Res 1999; 842(1): 224-229.
27. Qing Guo, Weiming Fu, Jun Xie, Hong Luo, Stephen J. Sells, James W. Geddes, Vimala Bondada, Vivek M. Rangnekar and Mark P. Mattson. Par-4 is a new mediator of neuronal degeneration associated with the pathogenesis of Alzheimer’s disease. Nature Medicine 1998; August, 4(8): 957-962
28. Qing Guo, Sylvia Christakos, Nic Robinson and Mark P. Mattson. Calbindin D28K Blocks the Pro-Apoptotic Actions of Mutant Presenilin-1: Reduced Oxidative Stress and Preserved Mitochondrial Function. Proc. Natl. Acad. Sci. USA. 1998; 95:3227-3232.
29. Qing Guo, Nic Robinson and Mark P. Mattson. Secreted beta-amyloid precursor protein counteracts the pro-apoptotic action of mutant presenilin-1 by activation of NF-kB and stabilization of calcium homeostasis. J. Biol. Chem. 1998; 273 (20): 12341-12351.
30. Inna Kruman, Qing Guo and Mark P. Mattson. Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells. J. Neurosci. Res. 1998, 51: 293-308.
31. Jeffrey N. Keller, Qing Guo, F.W. Holtsberg, A.J. Bruce-Keller, and Mark P. Mattson. Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 in linked to perturbed calcium homeostasis and enhanced oxyradical production. J. Neurosci. 1998; 18(12): 4439-4450.
32. K. Furukawa, Qing Guo, G. D. Schellenberg and M. P. Mattson. Presenilin-1 mutation alter NGF-induced neurite outgrowth, calcium homeostasis, and transcription factor (AP-1) activation in PC12 cells. J. Neurosci. Res. 1998; 52: 618-624.
33. Qing Guo, Bryce L. Sopher, Katsutoshi Furukawa, Dao G. Pham, George M. Martin and Mark P. Mattson. Alzheimer's PS-1 mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid -peptide: Involvement of calcium and oxyradicals. J. Neurosci. 1997; 17(11): 4212-4222
34. Mark P. Mattson, Nic Robinson, and Qing Guo. Estrogen stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1. NeuroReport 1997, 8: 3817-3821.
35. Mark P. Mattson and Qing Guo. Cellular and molecular neurobiology of presenilins: A role for the endoplasmic reticulum in the pathogenesis of Alzheimer’s disease? J. Neurosci. Res. 1997; 50: 505-513
36. Mark P. Mattson, Qing Guo, Katsutoshi Furukawa and Ward Peterson. Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer’s disease. J Neurochem. 1997, 70: 1-14.
37. Ward A. Peterson, Qing Guo, Boyd K. Hartmans, and Mark P. Mattson. Nerve growth factor-independent reduction in choline acetyltransferase activity in PC12 cells expressing mutant presenilin-1. J. Biol. Chem. 1997; 272(36): 22397-22400
38. Qing Guo, Katsutoshi Furukawa, Bryce L. Sopher, Dao G. Pham, Jun Xie, Nic Robinson, George M. Martin and Mark P. Mattson. Alzheimer’s PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid -peptide. NeuroReport 1996; 8: 379-383
39. Qing Guo, Pei-gen Kuang. Studies of Qingyangshen(II): Modulatory effect of co-treatment with Qingyangshen and diphenylhydantoin sodium on rat hippocampal c-fos expression during seizures. J Trad. Chin. Med. 1996; 16(1): 48-50;
40. Qingchun Song, Qing Guo, Hong Liu, Yuanyue Mu, S. Lang, and Ming Fan. Expression neurotrophin-3 mRNA induced by limbic seizures in adult rat hippocampus. Chin. Sci Bulletin. 1996; 41(24): 2083-2087
41. Hong Liu, Qing Guo, Yuanyue Mu, Ming Fan. Gene transfer of human neurotrophin-3 into myoblasts mediated by recombinant retrovirus. Communication of Neurochemistry (China). 1996; 18(3): 117-123
42. Qing Guo and P. Kuang. Studies of Qingyangshen (II): modulatory effect of co-treatment with qingyangshen and diphenylhydantoin sodium on rat hippocampal c-fos expression during seizures. J Tradit Chin Med 1996; 16(1): 48-50.
43. Qing Guo, Ming Fan, Hong Liu, Shu H. Liu Yuan Y. Mu and Si D. Gan. Long-term protective effect of neurotrophin-3 secreting myoblasts against kainic acid-induced excitotoxic lesions in the hippocampus. J Cell. Biochem. 1995; Suppl 21 (A): 393
44. Qing Guo and P. Kuang. Studies of qingyangshen (I): Differential expression of hippocampal c-fos proto-oncogene during kainic acid induced acute and chronic seizures. J Tradit Chin Med 1995; 15(4): 292-6.
45. Qing Guo, Pei-gen Kuang, Ming Fan and Si D. Gan. Changes in alpha- and beta- tubulin gene expressions in hippocampal formation during epileptogenesis. Chin. Sci Bull. 1995; 40(15): 1282-1286
46. Qing Guo, Ming Fan, Hong Liu, Shu H. Liu Yuan Y. Mu and Si D. Gan. Neurotrophin-3 gene transfer and expression in cultured myoblasts. Chin J Physiol, Sci. 1995; 11(2): 156-162;
47. Qing Guo, Pei-gen Kuang: Induction of c-fos mRNA in rat hippocampus by cholinergic and adrenergic agonists. Chin J Physiol. Sci. 1995;11(1): 90-93;
48. Qing Guo, and Pei-gen Kuang. Hippocampal quinolinic acid concentrations in epileptogenesis in rats. Acta Pharmalogica Sinica. (Zhongguo Yao Li Xue Bao) 1995; 16(5): 438-440.
49. Qing Guo, and Pei-gen Kuang. Expression of hippocampal c-fos proto-oncogene is reduced during kainic acid-induced chronic seizures. Chin. J Neurosci. 1995; 2(1) 88-93;
50. Qing Guo, Ming Fan, Hong Liu and Si D. Gan. Isolation and culture of satellite cells from regenerating skeletal muscle of adult rats. Chin. J Physiol. Sci. 1995; 11(2): 163-168;
51. Qing Guo, Pei-gen Kuang. Studies of Qingyangshen(I): differential expression of hippocampal c-fos proto-oncogene during kainic acid induced acute and chronic seizures. J Trad. Chin Med. 1995; 15(4): 292-296.
52. Qing Guo, Pei-gen Kuang. Quinolinic acid concentrations in cerebrospinal fluid and plasma of epileptic patients. Chin. J Neurol. Psychiatry. 1995; 28(4): 531-533
53. Qing Guo, Si-de Gan. Progress in gene therapy of neurological disorders: A review. Basic and Clinical Medicine. 1995; 12(3): 289-296
54. Qing Guo and Peigen Kuang. Effect of Qingyangshen on hippocampal  and -tubulin gene expression during kainic acid induced epileptogenesis. J Trad Chin. Med. 1993; 13(4): 281-286;
55. Qing Guo, Zuo-zhou Liu and Hong-wei Liao. Burst characteristics of normal and epileptogenic hippocampal complex spike cells. Chin J Appl. Physiol. 1990; 6(1): 35-40.
56. Qing Guo, Zuo-zhou Liu and Wei-hong Liao. A study of epileptiform hippocampal unit activity induced by intracerebroventricular injection of kainic acid in rats. J Med Coll. PLA. 1989; 4(3): 272-276.
57. Qing Guo, Atrial natriuretic polypeptide in the central nervous system. Prog. Physiol. Sci. 1987; 18(4): 357-359.